Carbon-14 dating at Tell Ramad, on the outskirts of Damascus, suggests that the site may have been occupied since the second half of the seventh millennium BC, possibly around 6300 BC. However, evidence of settlement in the wider Barada basin dating back to 9000 BC exists, although no large-scale settlement was present within Damascus walls until the second millennium BC.
Damascus was part of the ancient province of Amurru in the Hyksos Kingdom, from 1720 to 1570 BC. Some of the earliest Egyptian records are from the 1350 BC Amarna letters, when Damascus-(called Dimasqu) was ruled by king Biryawaza. The Damascus region, as well as the rest of Syria, became a battleground circa 1260 BC, between the Hittites from the north and the Egyptians from the south, ending with a signed treaty between Hattusili and Ramsis II where the former handed over control of the Damascus area to Ramesses II in 1259 BC. The arrival of the Sea Peoples, around 1200 BC, marked the end of the Bronze Age in the region and brought about new development of warfare. Damascus was only the peripheral part of this picture which mostly affected the larger population centers of ancient Syria. However, these events had contributed to the development of Damascus as a new influential center that emerged with the transition from the Bronze Age to the Iron Age.
Damascus is mentioned in Genesis 14:15 as existing at the time of the War of the Kings. (However, the verse can also be understood to mean that Damascus existed when Genesis was written – by tradition around the 13th century BC, and several centuries later according to some scholars – regardless of whether Damascus existed at the time of the War of the Kings.) According to the 1st century Jewish historian Flavius Josephus in his twenty-one volume Antiquities of the Jews, Damascus (along with Trachonitis), was founded by Uz, the son of Aram. Elsewhere, he stated:
Nicolaus of Damascus, in the fourth book of his History, says thus: "Abraham reigned at Damascus, being a foreigner, who came with an army out of the land above Babylon, called the land of the Chaldeans: but, after a long time, he got him up, and removed from that country also, with his people, and went into the land then called the land of Canaan, but now the land of Judea, and this when his posterity were become a multitude; as to which posterity of his, we relate their history in another work. Now the name of Abraham is even still famous in the country of Damascus; and there is shown a village named from him, The Habitation of Abraham.